Weightwell GLP-1 Activator with

1) Berbevis® (Berberine with 10x better absorption),

2) Quercetin and

3) L-Glutamin

Weightwell works very effectively by activating L-cells which produce more of your own GLP-1 hormone: 

• L-cell's stimulation (with Berbevis®, Hops, L-Phenylalanine), 
• L-cell preservation (with Quercetin), 
• and L-Cell support (with L-Glutamine). 

Best kept secret to weight loss:

It is impossible to gain weight if you have little to no insulin. 

So if you can control/keep insulin low, you will never gain weight again! 

And GLP-1 helps to lower insulin and to satiate hunger!  

View The Weight Loss Stack

What is a natural GLP-1 activator?

GLP-1 (Glucagon-Like Peptide-1) is the master hormone for metabolic control in the body.

GLP-1 controls Insulin (too much sugar/energy => then store extras in tissue => more and bigger fat cells) and glucagon (too little sugar/energy => then release stored sugar => burn fat => provide energy (glucose and ketones) to the brain => no more hunger).

GLP-1 is produced by L-cells in the gut and helps regulate/control the process to turn food into energy.

GLP-1 also controls the rate at which food moves from the stomach to the intestine, where nutrients then supply energy. The slower the better. Don't wolf your food down. 

Which means GLP-1 lowers appetite and hunger cravings. It is much easier to eat less if you don't get hungry all the time.

Therefore, GLP-1 regulates blood sugar and weight gain and loss.

GLP-1 is rapidly broken down by the DPP-4 enzyme. Quercetin helps inhibit DPP-4 and extend GLP-1 activity. 

What Are L-Cells?

L-cells are hormone-secreting cells in the lower intestine. They sense nutrients and then release GLP-1, PYY, and oxyntomodulin.

So the Weightwell GLP-1 Activator formula targets 

• L-cell's stimulation (with Berbevis, Hops, L-Phenylalanine), 
• preservation (with Quercetin), 
• and support (with L-Glutamine). 

How Weightwell Works in more detail:

• Step 1: Stimulate GLP-1 by triggering L-cells to produce GLP-1 with Berbevis, Hops and L-Phenylalanine.
• Step 2: Preserve GLP-1 by inhibiting breakdown by DPP-4 with Quercetin.
• Step 3: Support L-cells by fueling and repairing gut lining with L-Glutamine.
• Step 4: Take Weightwell with Nucleo, which has 12 ingredients (out of 60) focusing on supporting/restoring the gut/L-cells and is therefore ideal as a Low Glycemic Index meal replacement or supplement providing sustained energy without spiking the blood sugar/insulin.

Known Benefits of Berberine:

1. Blood Sugar Regulation

• Activates AMPK (AMP-activated protein kinase), the "metabolic master switch"
• Aids metabolic syndrome markers
• Shown to lower fasting blood glucose and HbA1c in type 2 diabetics
• Comparable in some studies to metformin for glycemic control
• Improves insulin sensitivity and reduces insulin resistance
• Balances post-meal blood sugar  

2. Cardiovascular (Heart) Health

• Lowers total cholesterol, LDL ("bad") cholesterol, and triglycerides
• Raises HDL ("good") cholesterol
• Reduces blood pressure
• May protect against atherosclerosis (arterial plaque buildup)
• Has shown antiarrhythmic properties (helps regulate heart rhythm)

3. Weight Management

• Inhibits fat cell growth (adipogenesis), especially visceral fat
• Boosts metabolism via AMPK activation
• Reduce body mass index (BMI) and waist circumference
• Naturally controls appetite and cravings 

4. Gut Health & Antimicrobial Effects

• Broad-spectrum antimicrobial activity against bacteria, viruses, fungi, and parasites
• Effective against H. pylori (a major cause of stomach ulcers)
• Helps treat infectious diarrhea
• Positively modulate the gut microbiome

5. Anti-Inflammatory & Antioxidant Effects

• Suppresses pro-inflammatory cytokines (e.g., TNF-α, IL-6)
• Reduces oxidative stress by neutralizing free radicals
• Help with chronic inflammatory conditions

6. Liver Health

• Reduces liver fat accumulation
• Beneficial for non-alcoholic fatty liver disease (NAFLD)
• Lowers liver enzymes (ALT/AST) in liver disease patients
• Protect against liver fibrosis
  

7. Polycystic Ovary Syndrome (PCOS)

• Improves insulin sensitivity in women with PCOS
• Helps regulate menstrual cycles
  

8. Brain & Neurological Health

• Have neuroprotective properties
• Shows potential in reducing amyloid plaques (linked to Alzheimer's)
• Supports dopamine and serotonin regulation (potential antidepressant effects)
• May reduce neuroinflammation

9. Anticancer Properties (Preliminary)

• Shown in lab studies to inhibit the growth of certain cancer cells (colorectal, breast, liver)
• Induces apoptosis (programmed cell death) in cancer cells
  

10. Bone Health

• Stimulate bone formation and reduce bone loss, showing promise for osteoporosis prevention

Why This Formula?

By tapping into the body's own GLP-1 production, the Weightwell formulation was engineered as a natural, clinically backed alternative solution to chemical GLP-1 activators like Ozempic and Wegovy.

It is a natural, non-injectable, sustainable alternative or adjunct therapy.

Berbevis® (Berberine Phytosome): 

A scientific study tested Berbevis® to see if it could help people who struggle with high blood sugar. The study was done properly — meaning some people got the real supplement and others got a "fake" pill (called a placebo), and nobody knew which one they were taking until the end.

After 60 days, here's what they found:

1 - Better Blood Sugar

People who took Berbevis® had better blood sugar levels after fasting (not eating for a period of time) compared to the group who took the placebo. Keeping blood sugar balanced is important because when it stays too high for too long, it can lead to serious health problems like diabetes.

2 - Improved Cholesterol Ratios

Total cholesterol, triglycerides (another type of fat), and certain cholesterol/HDL ratios all moved in a healthier direction for the people taking Berbevis®.

3 - Improved Insulin Resistance

Insulin is the hormone your body uses to process sugar. When your body stops responding to it properly, that's called insulin resistance — and it's a warning sign for diabetes. People taking the supplement showed better insulin levels and a better score on a test that measures insulin resistance.

4 - Losing Visceral Fat

People taking Berbevis® also tended to have less visceral fat (the dangerous fat that builds up around your organs), less total body fat, and a smaller waist size.

5 - Totally Safe

Nobody reported any side effects. The supplement appeared to be safe for everyone in the study.

In short, this study suggests Berbevis® help the body manage blood sugar, cholesterol, and body fat more effectively.

Phytosome is a patented delivery system that binds natural plant compounds to phospholipids (the same molecules found in cell membranes). This allows the active ingredients to pass more easily through the gut wall and into the bloodstream. Compared to conventional extracts, Phytosome enhances absorption by up to 10 times and significantly improves the effectiveness of plant-based compounds like Berberine. 

Hops Extract: Binds to bitter taste receptors (T2Rs) in the gut lining, which activates L-cells to release satiety hormones GLP-1 and CCK.

L-Phenylalanine: An amino acid proven to stimulate L-cells to release GLP-1 and PYY, reducing appetite and blood sugar spikes.

L-Glutamine: A restorative compound that fuels intestinal cells and improves L-cell health for more reliable GLP-1 production.

Nucleo contains 12 nutritional solutions to improve gut health including its own dose of L-Glutamine, spirulina, digestive enzymes and Omega 3.

Quercetin: A natural inhibitor of DPP-4, the enzyme that degrades GLP-1. This extends GLP-1 hormone activity in the bloodstream. 

Together, these ingredients address not just hormone stimulation, but preservation and gut-based support — offering a complete solution.

Unlike synthetic GLP-1 receptor agonists like Ozempic, this formula works through natural biochemical pathways to empower long-term health without abrupt crashes or side effects. 

This isn't just a list of ingredients — it's a precisely engineered ecosystem designed for synergy.

Weight loss protocols:

We have seen that intermittent fasting, along with a high protein, high fat and low carb diet as a lifestyle, is the most effective way to control sustainable weight loss.

It is then a perfect match to take 2 x Weightwell capsules with 50g of Nucleo as a first meal of the day in an intermittent fasting weight loss protocol.

On its own Nucleo (formulated with a low GI similar to lentils and with a focus to heal the gut lining) helps to take away cravings, but when taking 2 (or even only 1) capsules of Weightwell with your 50g of Nucleo as a meal, you will notice significant lower insulin, blood sugar stabilization and loss of cravings.

Taking a 12 strain probiotic such as Rawbiotics will further improve the gut health.

When starting with an intermittent fasting lifestyle it is important not to start with 15 or 16 hours of daily fasting. Rather, help your body to get used to fasting over weeks and months for it to become a sustainable lifestyle,. Starting with 12 hour fast and increasing slowly over 4 months to 13 hours and then 4 months later to 14 hours etc... is much easier and more sustainable.  

If you cannot fast for so many hours then take one Weightwell capsule with breakfast (ideally make Nucleo your breakfast) and take one Weightwell capsule with your lunch. You can experiment by sometimes taking the capsules a few hours later or when you feel hungry. Take only two capsules per day,

Of course you can use the Weightwell without Nucleo if you prefer other high protein, high fat, low carb foods. However we believe Nucleo is the most affordable gram for gram per 50g dose.

Two capsules (only 2 per day) contain the following:  

Ingredient	Dosage	Function
Berbevis® (Berberine Phytosome™)	500 mg	Hero ingredient. Activates GLP-1 hormone via AMPK pathway. Improves insulin & metabolic health. 10x more absorbable.
Hops Flower Extract (10:1)	500 mg	Activates bitter taste receptors in gut → triggers GLP-1 + CCK release → boosts fullness & gut-brain signals.
L-Phenylalanine	100 mg	Amino acid that directly turns on GLP-1 + PYY → controls hunger & steadies blood sugar.
L-Glutamine	100 mg	Fuels gut lining, supports L-cell health, boosts GLP-1 output, and helps repair gut wall.
Quercetin	15 mg	Natural DPP-4 blocker → slows GLP-1 breakdown → keeps it active longer.

 

 

View The Weight Loss Stack

 

Frequently Asked Questions

Can this be used with GLP-1 medicine like Ozempic or Wegovy?

Yes. It complements and enhances effects, helping with metabolic resilience. The idea is to wean off the drugs until you only use the Weightwell natural alternative.

Can this help people wean off injectables?

Yes. It supports your body's natural GLP-1 system during the transition. 

Why Berbevis® over generic berberine?

10x better absorption, clinically proven, award-winning, no irritation. 

Can Nucleo and Weightwell be taken by diabetics?

Yes, it works very effectively to control blood sugar for both Type 1 and Type 2 diabetics. In fact it works for anyone with metabolic imbalance — PCOS, cravings, insulin resistance or general weight loss problems. Nucleo has a Glycemic Index (GI) of 36 which is low and therefore ideal to stabilize blood sugar.

Can Weightwell be taken without Nucleo and have the same impact?

Yes you can take Weightwell with any low GI food. However, we believe with 43+ ingredients Nucleo is the most affordable meal replacement or supplement gram for gram per 50g dose. 

How long to see results?

Clinically shown results in 30-60 days. 

Can Weightwell be used long-term?

Yes. All ingredients are safe, natural, and suitable for long-term use. 

Can Weightwell be used by children trying to lose weight?

Since Berberine has an influence on hormonal balancing, we would not recommend children below 14 to take it. Children between 14 and 18 should consult with their doctor or dietician when taking it. Children should rather focus on healthy diet and activity/sport to achieve weight loss goals.